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Well, there are a number of third party applications available that support DB2 but I am not an expert in the options available for the particular types of applications you cite.
I think your best approach would be to work with your IBM sales person and technical support folks for guidance in the available software that meets your needs and runs on the DB2 and z/OS platform you seek to support. Indeed, IBM themselves may be able to offer application solutions for some of your needs.
You might want to browse around the IBM Web site and check out its PLM offerings.
Good luck.
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